Milwaukee led Philadelphia 4-2 after three innings, but the Phillies scored one run in each of the next four innings to win 6-4 on Friday night at Miller Park.
Christian Yelich hit his 20th home run after missing the week with back spasms, and Milwaukee got eight hits in the loss.
Chase Anderson pitched four innings before giving way to the bullpen.
The three-game series continues Saturday night at Miller Park.
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