OPRAH's security took no chances when a fight broke out near her on a New York City sidewalk yesterday.  Oprah was leaving the CBS building, and it looked like she was about to greet a crowd of autograph hounds.

But before she could, two guys started BRAWLING, and some glass got broken in the process.  Oprah's security rushed her to her car, and that was that.

There's no word if these guys were there for autographs, or if it was just a case of random fisticuffs.  But there's video, so we've got that going for us.  

(WARNING!!!  This video contains uncensored profanity.)